This study aims to evaluate the role of Home-Based Enterprises (HBEs) in enhancing economic resilience in the West Bank by assessing their economic contribution, identifying the challenges they face, and analyzing their potential to support households and communities during crises. To what extent do HBEs strengthen economic resilience in the West Bank, and how do structural, financial, and institutional factors shape their performance and sustainability? HBEs function as key adaptive mechanisms that bolster economic resilience by creating income-generating opportunities, especially for women, and sustaining localized production during periods of political and economic instability—despite operating within a constrained and vulnerable environment. A mixed-method design integrates: 1) Quantitative analysis of the 2022 Informal Sector and Informal Employment Survey (PCBS), covering 104,169 informal projects, including 14.3% HBEs. 2) Qualitative SWOT analysis assessing internal strengths/weaknesses and external opportunities/threats influencing the sector. HBEs contribute approximately 7% of West Bank GDP (around USD 1.2 billion) and provide livelihoods for 185,000 individuals, with women representing over 60% of participants. Their low-cost and flexible nature enables them to endure economic shocks. However, HBEs face significant barriers: limited access to finance (69%), poor infrastructure, technological gaps, informality (98.8% unregistered), and restricted market reach. Opportunities identified include new legal reforms, expanded microfinance, and digital marketing. HBEs are essential socio-economic institutions that enhance economic resilience in crisis-prone contexts. Strengthening this sector requires targeted policy interventions focused on improving financial access, infrastructure, digital capabilities, and supportive regulatory environments.